NFL odds Week 1: Opening lines for every game

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Here is everything you need to know about NFL odds for Week 1 – the point spread, moneyline and total scoring over / under for every game (with all NFL odds via FOX Bet).

For more, from gambling-friendly schedules featuring live, updating odds to expert analysis and the day’s most-bet games, check out the all-new “NFL Odds“section on the FOX Sports App and FOXSports.com!

The defending Super Bowl champion Los Angeles Rams and 2021 Offensive Player of the Year, wide receiver Cooper Kupp, open the season by playing host to quarterback Josh Allen and the Buffalo Bills.

Tom Brady and the Tampa Bay Buccaneers wrap up the slate of games Sunday Sept. 11 by playing at the Dallas Cowboys.

Week 1 wraps up with the Denver Broncos and new quarterback Russell Wilson traveling to Seattle to take on Wilson’s former team the Seahawks on Monday Night Football on Sept. 12.

Here are the early lines posted for opening week (via FOX Bet):

WEEK 1 GAMES

Buffalo Bills @ Los Angeles Rams (8:20 pm ET Sept. 8, NBC)

Point spread: Rams -1 (Rams favored to win by more than 1 point, otherwise Bills cover)
Moneyline: Rams -118 favorites to win (bet $ 10 to win $ 18.47 total); Bills +100 underdogs to win (bet $ 10 to win $ 20 total)
Total scoring over / under: 52 points scored by both teams combined

New Orleans Saints @ Atlanta Falcons (1 pm ET Sept. 11, FOX)

Point spread: Saints -4 (Saints favored to win by more than 4 points, otherwise Falcons cover)
Moneyline: Saints -189 favorites to win (bet $ 10 to win $ 15.29 total); Falcons +160 underdogs to win (bet $ 10 to win $ 26 total)
Total scoring over / under: 42 points scored by both teams combined

San Francisco 49ers @ Chicago Bears (1 pm ET Sept. 11, FOX)

Point spread: 49ers -6.5 (49ers favored to win by more than 6.5 points, otherwise Bears cover)
Moneyline: 49ers -250 favorites to win (bet $ 10 to win $ 14 total); Bears +210 underdogs to win (bet $ 10 to win $ 31 total)
Total scoring over / under: 42 points scored by both teams combined

Pittsburgh Steelers @ Cincinnati Bengals (1 pm ET Sept. 11, FOX

Point spread: Bengals -6.5 (Bengals favored to win by more than 6.5 points, otherwise Steelers cover)
Moneyline: Bengals -278 favorites to win (bet $ 10 to win $ 13.60 total); Steelers +225 underdogs to win (bet $ 10 to win $ 32.50 total)
Total scoring over / under: 44.5 points scored by both teams combined

Philadelphia Eagles @ Detroit Lions (1 pm ET Sept. 11, FOX)

Point spread: Eagles -4 (Eagles favored to win by more than 4 points, otherwise Lions cover)
Moneyline: Eagles -189 favorites to win (bet $ 10 to win $ 15.29 total); Lions +160 underdogs to win (bet $ 10 to win $ 26 total)
Total scoring over / under: 46.5 points scored by both teams combined

Are Cowboys the best team in the NFC East? I SPEAK FOR YOURSELF

Are Cowboys the best team in the NFC East?  I SPEAK FOR YOURSELF

The Dallas Cowboys are the reigning NFC East champions, but Bleacher Report wrote that their offense will take a step back this season after losing Amari Cooper and Cedric Wilson Jr. They have tougher competition with the Philadelphia Eagles after trading for AJ Brown. LaVar Arrington explains why the Cowboys are NOT the best team in the NFC East.

New England Patriots @ Miami Dolphins (1 pm ET Sept. 11, CBS)

Point spread: Dolphins -3 (Dolphins favored to win by more than 3 points, otherwise Patriots cover)
Moneyline: Dolphins -149 favorites to win (bet $ 10 to win $ 16.71 total); Patriots +125 underdogs to win (bet $ 10 to win $ 22.50 total)
Total scoring over / under: 45 points scored by both teams combined

Baltimore Ravens @ New York Jets (1 pm ET Sept. 11, CBS)

Point spread: Ravens -4.5 (Ravens favored to win by more than 4.5 points, otherwise Jets cover)
Moneyline: Ravens -189 favorites to win (bet $ 10 to win $ 15.29 total); Jets +160 underdogs to win (bet $ 10 to win $ 26 total)
Total scoring over / under: 45 points scored by both teams combined

Jacksonvile Jaguars @ Washington Commanders (1 pm ET Sept. 11, CBS)

Point spread: Commanders -4 (Commanders favored to win by more than 4 points, otherwise Jaguars cover)
Moneyline: Commanders -189 favorites to win (bet $ 10 to win $ 15.29 total); Jaguars +160 underdogs to win (bet $ 10 to win $ 26 total)
Total scoring over / under: 43 points scored by both teams combined

Cleveland Browns @ Carolina Panthers (1 pm ET Sept. 11, CBS)

Point spread: Browns -4.5 (Browns favored to win by more than 4.5 points, otherwise Panthers cover)
Moneyline: Browns -200 favorites to win (bet $ 10 to win $ 15 total); Panthers +170 underdogs to win (bet $ 10 to win $ 27 total)
Total scoring over / under: 43.5 points scored by both teams combined

Indianapolis Colts @ Houston Texans (1 pm ET Sept. 11, CBS)

Point spread: Colts -8 (Colts favored to win by more than 8 points, otherwise Texans cover)
Moneyline: Colts -345 favorites to win (bet $ 10 to win $ 12.90 total); Texans +280 underdogs to win (bet $ 10 to win $ 38 total)
Total scoring over / under: 44 points scored by both teams combined

New York Giants @ Tennessee Titans (4:25 pm ET Sept. 11, FOX)

Point spread: Titans -6.5 (Titans favored to win by more than 6.5 points, otherwise Giants cover)
Moneyline: Titans -303 favorites to win (bet $ 10 to win $ 13.30 total); Giants +245 underdogs to win (bet $ 10 to win $ 34.50 total)
Total scoring over / under: 44 points scored by both teams combined

Green Bay Packers @ Minnesota Vikings (4:25 pm ET Sept. 11, FOX)

Point spread: Packers -1.5 (Packers favored to win by more than 1.5 points, otherwise Vikings cover)
Moneyline: Packers -125 favorites to win (bet $ 10 to win $ 18 total); Vikings +105 underdogs to win (bet $ 10 to win $ 20.50 total)
Total scoring over / under: 49 points scored by both teams combined

Kansas City Chiefs @ Arizona Cardinals (4:25 pm ET Sept. 11, CBS)

Point spread: Chiefs -3 (Chiefs favored to win by more than 3 points, otherwise Cardinals cover)
Moneyline: Chiefs -149 favorites to win (bet $ 10 to win $ 16.71 total); Cardinals +125 underdogs to win (bet $ 10 to win $ 22.50 total)
Total scoring over / under: 53 points scored by both teams combined

Las Vegas Raiders @ Los Angeles Chargers (4:25 pm ET Sept. 11, CBS)

Point spread: Chargers -4 (Chargers favored to win by more than 4 points, otherwise Raiders cover)
Moneyline: Chargers -189 favorites to win (bet $ 10 to win $ 15.29 total); Raiders +160 underdogs to win (bet $ 10 to win $ 26 total)
Total scoring over / under: 51.5 points scored by both teams combined

Tampa Bay Buccaneers @ Dallas Cowboys (8:20 pm ET Sept. 11, NBC)

Point spread: Buccaneers -2 (Buccaneers favored to win by more than 2 points, otherwise Cowboys cover)
Moneyline: Buccaneers -125 favorites to win (bet $ 10 to win $ 18 total); Cowboys +105 underdogs to win (bet $ 10 to win $ 20.50 total)
Total scoring over / under: 51.5 points scored by both teams combined

Denver Broncos @ Seattle Seahawks (8:15 pm ET Sept. 12, ABC / ESPN)

Point spread: Broncos -4 (Broncos favored to win by more than 4 points, otherwise Seahawks cover)
Moneyline: Broncos -189 favorites to win (bet $ 10 to win $ 15.29 total); Seahawks +160 underdogs to win (bet $ 10 to win $ 26 total)
Total scoring over / under: 41.5 points scored by both teams combined

Looking for even more NFL content? Head over to the NFL section on the FOX Sports app and website for all the latest news, and make sure to favorite the NSFL and your favorite team – or teams! – while you’re there.

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